International Bio-Fluid Mechanics Symposium and Workshop

December 12-14, 2003,
Lees-Kubota auditorium, California Institute of Technology, Pasadena, California, USA

Under the Auspices of the
US National Committee on Biomechanics (USNCB)
The Biomedical Engineering Society (BMES)
International Federation for Medical and Biological Engineering (IFMBE)

Organizing Committee:
Einav S - Chairman, Ethier R, Gharib M, Kamm R, Liepsch D, Yoganathan A.

Advisory Board:
Bluestein D, Chandran KB, Dewey F, Elad D, Friedman M, Giddens D, Kajiya F, Kassab G, Moore J, Oddu C, Rambod E, Schroter R, Spaan J, Steinman D, Tarbell J, Taylor C, Weinbaum S, Yamaguchi T, Zamir M

The International Symposium on Bio-Fluid Mechanics will review major milestones that were achieved in the past decade and define the so called "show-stoppers" in reaching a comprehensive understanding of bio-fluid Mechanics and Cardiovascular Hemodynamics from cell to organs. In this respect, we face major challenges in defining critical questions and identifying tools that are required to answer these questions.

We aim to explore and discuss the foundations of fluid mechanics as applied to biological systems. We will explore new experimental and modeling tools to describe complex bio-flow patterns, interstitial fluid patterns and tissue perfusion. There is no doubt that a combination of experimental and computational approaches armed with advanced computational and diagnostic modalities, will be needed to achieve our objectives. We aim to present in the Symposium a critical review of past approaches and offer road-maps for future research strategies that can help to determine the link between biological flow patterns and arterial disease. We will also define one or two gold standard data sets that will serve as benchmarks for code validation/mesh testing. We wish to come out of the meeting with a "code of standards" for the use of fluid mechanics in biological and medical systems, including issues related to gold standards.

PRELIMINARY PROGRAM

Friday, December 12, 2003

Plenary Talks
Peter Davies: Shear Stress and the Endothelium: Spatial Genomics moves In Vivo
Morton Friedman: Realizing the Potential of Biofluid Mechanics in the Biological Century

Saturday, December 13, 2003

Blood Flow in Major Blood Vessels - Modeling and Experiments
Theme Leaders: Morton Friedman, Don Giddens, Takeshi Karino
Giddens, Don: Observed Asymmetric Atherosclerotic Plaque Localization in the Coronary Arteries May Relate to Flow Patterns in the Human Ascending Aorta
Karino, Takeshi: Flow-Dependent Concentration Polarization of Lipoproteins as a Localizing Mechanism of Vascular Diseases
Berger, Stanley: Flow and Fluid Forces in Stenotic Arteries
Niedere, Peter: Fluid-Solid Interactions as a Possible Mechanism for Minor Neck Injuries Due to Whiplash
Fischer, Paul: Transitional Flow in Stenosed Carotid Arteries
Cho, Young: Whole Blood Shear Rate-Viscosity Profiles: Using New Technology to Establish Clinical Utility of a Basic Hemorheological Measure

Flow in Artificial Organs and Vascular Devices:
Theme Leaders: Ajit Yoganathan, KB Chandran
Chandran, KB: Fluid-Structure Interaction Algorithm Development for Native and Prosthetic Heart Valve: Functional Analysis
Vesely, Ivan: The Role of the Pressurized Aortic Root in the Opening of the Aortic Valve and its Associated Fluid Dynamics
Bluestein, Danny: Platelet Activation and Free Emboli Formation in Flow Past Mechanical Heart Valves
Gharib, Mory: On the Issue of Optimal Trans-Mitral Flow
Moore, James: Stent-Induced Changes in Hemodynamics: Flow Patterns, Platelet Deposition and Restenosis
Sotiropoulos, Fotis: Toward Quantitatively Accurate Modeling of Cardiovascular Flows: Integrating High Resolution CFD & Experimental Techniques
Vosse van de, Frans: Valve-Valve Interaction in a Simplified Left Ventricular Model

Status Papers:

Cellular Fluid Mechanics and Mechano-Transduction
Theme Leaders: Forbes Dewey, John Tarbell, Shelly Weinbaum
Dewey, Forbes: Cellular Fluid Mechanics and Mechano-Transduction
Kamm, Roger: Probing Mechanotransduction in Living Cells
Tarbell, John: Heparan Sulfate Proteoglycan is a Mechanosensor on Endothelial Cells
Vink, Hans: Visualization of structure and function of the Endothelial Cell Glycocalyx: Hydrodynamic Interface Between Blood and Vessel Wall
Weinbaum, Sheldon: On the Transmission of Fluid Shear Stress Across the Endothelial Glycocalyx to the Actin Cytoskeleton

Flow Imaging and Computing
Theme Leaders: Charles Taylor, David Steinman, Vittorio Cristini
Steinman, David: Image-Based CFD of Large Artery Hemodynamics: Towards the Next Decade
Taylor, Charles: Simulation-Based Medical Planning for Cardiovascular Disease
Redaelli, Alberto: Numerical Investigation of Y Shaped Coronary Artery By-Pass Grafts
Cheng, Christopher: In Vivo Quantification of Large Vessel Hemodynamics Using Exercise Stress Magnetic Resonance Imaging
Cristini, Vittorio: Adaptive Multiscale Numerical Simulation Blood Rheology and Red Cell Dynamics in the Microcirculation
Elad, David: Feto-Maternal Blood Perfusion in the Placental Vasculature
Meng, Hui: CFD and Holographic PIV for Hemodynamic Intervention of Intracranial Aneurysms
Walker, Peter: MRI Guided CFD Simulation of Species Transport in Subject Specific Carotid Arteries: Effect of Wall Reaction Mechanism

Fluid Mechanics in Micro and Nano Scales
Theme Leaders: Flavio Noca, Dorian Liepmann
Noca, Flavio: Nanoscale Fluid Mechanics of Ciliated Structures
Hove, Jay: Zebrafish, a Living Microfluidic System
Liepmann, Dorian: Complex Fluid Flows in MEMS Devices

Shear Stress Biology of the Endothelium:
Theme Leaders: Peter Davies, Jos Spaan, Rob Krams
DePaola, Natacha: Functional Compartmentalization of Vascular Endothelium Disturbed Flow
Lasheras, Juan: Cell-Activation by Shear Stresses in Abdominal Aortic Aneurysms
Spaan, Jos: Shear and Pressure Effects on Remodeling of Resistance Vessels
Kassab, Ghassan: No Production is Significantly Reduced in Reverse Flow
Atherton, Mark: A Design Approach to Spiral Artery Haemodynamics: Distribution of Wall Shear and Relevance to Atherogenesis.
Krams, Rob: The Role of Shear Stress in Atherosclerosis

Sunday, December 14, 2003

Correlation of Hemodynamic Events with Clinical and Pathological Observations.:
Theme Leaders: Takami Yamaguchi, Baruch Lieber, Maria Siebes
Lieber, Baruch: Functional Angiography
Siebes, Maria: Coronary Stenosis and Microvascular Hemodynamics Assessed with Combined Pressure and Flow Velocity Measurements
McGloughlin, Tim: Future Approaches to Graft/Artery Bypass Surgery
Wentzel, Jolanda: Image Based Modeling of Shear Stress and its Application in Coronary Arteries in Patients
Spencer Sherwin: Biglobal Instabilities of Steady and Pulsatile Flows in a 75% Axisymmetric Stenotic Tube
Yamaguchi, Takami: Application of Computational Biomechanics to Clinical Cardiovascular Medicine
Westerweel, Jerry: Shear stress responsiveness in an embryonic chicken Heart
Sideman, Sam: Intracellular Control Mechanisms of Cardiac Energetics
Holmes, Jeff: Measuring, Modeling, and Parameterizing Left Ventricular Wall Motion as Blood Flow Boundary.

Cardiac Hemodynamics, Coronary Circulation and Interventional Cardiology:
Theme Leaders: Fumihiko Kajiya, Mair Zamir, Stephane Carlier
Zamir, Mair: Towards an "Unlumped" Model of the Coronary Circulation
Carlier, Stephane: A critical appraisal of the intravascular ultrasound and physiological methods to evaluate moderate coronary stenosis: do they reduce the rates of coronary events?
Verdonck, Pascal: Validation of a Fluid-Structure Interaction Model of the Aortic Heart Valve Motion
Iwasaki, Tatsuo: In VivoVisualization study of morphology and Vasoreactivity of Perialveolar and Coronary Microcirculation in Rats with Experimental Pulmonary Hypertension
Lemma, Massimo: Effects of Heart Rate on Phasic Y-Graft Blood Flow and Flow Reserve in Patients with Complete Arterial Myocardial Revascularization: An Intravascular Doppler Catheter Study
Kajiya, Fumihiko: Functional Analysis of Coronary Microcirculation By Novel Microvisualization Technologies

Air Flow in Large Airways
Theme Leaders: Jim Grotberg, Chris Bertram
Bertram, Chris: Flow-Field Measurement for Collapsible Tubes
Gaver, Don: The Use of Biofluid Mechanics Investigations to Evaluate the Stimulus for Interfacial-Stress-Induced Damage to Airway Epithelial Cells During Infant and Acute Respiratory Distress Syndrome
Grotberg, Jim: Liquid Plug Transport in Airway Models-Experiment and Theory
Trease, Harold: Viscoelastic Modeling of the Respiratory Tract

Pedagogical and Education Issues in Teaching Bio-Fluid Mechanics:
Theme Leaders: Danny Bluestein, James Moore
Bluestein, Danny: Developing and Teaching a Biofluids Course -The Stony Brook Experience
Chandran, KB: Fluid mechanics in the human circulation: An introductory textbook in biofluid mechanics
Ethier, C Ross: Effective Biofluids Teaching
Holmes, Jeffrey: Teaching Biofluids-Columbia University experience
Moore, James: Class Demonstrations and Laboratory Experiments for Biofluids Teaching
Zamir, Mair: Teaching the Physics and Mathematics of Pulsatile Flow: Some Challenges

Working Groups on Conference Themes. The Participants will be divided to ten groups, according to the Themes. All Young Invitees will participate, as well.

General Discussion on Position Headlines